[HTML][HTML] Expression of regulated secretory proteins is sufficient to generate granule-like structures in constitutively secreting cells

N Beuret, H Stettler, A Renold, J Rutishauser… - Journal of Biological …, 2004 - ASBMB
The formation of secretory granules and regulated secretion are generally assumed to occur
only in specialized endocrine, neuronal, or exocrine cells. We discovered that regulated
secretory proteins such as the hormone precursors pro-vasopressin, pro-oxytocin, and pro-
opiomelanocortin, as well as the granins secretogranin II and chromogranin B but not the
constitutive secretory protein α 1-protease inhibitor, accumulate in granular structures at the
Golgi and in the cell periphery in transfected COS-1 fibroblast cells. The accumulations were …