Use of the oral neuraminidase inhibitor oseltamivir in experimental human influenza: randomized controlled trials for prevention and treatment
FG Hayden, JJ Treanor, RS Fritz, M Lobo, RF Betts… - Jama, 1999 - jamanetwork.com
ContextInfluenza virus neuraminidase is thought to be essential for virus replication in
humans; however, to date, available neuraminidase inhibitors are limited to zanamivir,
which is topically administered. ObjectiveTo determine the safety, tolerability, and antiviral
activity of oral neuraminidase inhibitor oseltamivir (GS4104/Ro64-0796) for prevention and
the early treatment of influenza in experimentally infected humans. DesignTwo randomized,
double-blind, placebo-controlled trials conducted between June and July 1997 …
humans; however, to date, available neuraminidase inhibitors are limited to zanamivir,
which is topically administered. ObjectiveTo determine the safety, tolerability, and antiviral
activity of oral neuraminidase inhibitor oseltamivir (GS4104/Ro64-0796) for prevention and
the early treatment of influenza in experimentally infected humans. DesignTwo randomized,
double-blind, placebo-controlled trials conducted between June and July 1997 …