1, 25-dihydroxyvitamin D3-independent stimulatory effect of estrogen on the expression of ECaC1 in the kidney
M Van Abel, JGJ Hoenderop, O Dardenne… - Journal of the …, 2002 - journals.lww.com
Estrogen deficiency results in a negative Ca 2+ balance and bone loss in postmenopausal
women. In addition to bone, the intestine and kidney are potential sites for estrogen action
and are involved in Ca 2+ handling and regulation. The epithelial Ca 2+ channel ECaC1 (or
TRPV5) is the entry channel involved in active Ca 2+ transport. Ca 2+ entry is followed by
cytosolic diffusion, facilitated by calbindin-D 28K and/or calbindin-D 9k, and active extrusion
across the basolateral membrane by the Na+/Ca 2+-exchanger (NCX1) and plasma …
women. In addition to bone, the intestine and kidney are potential sites for estrogen action
and are involved in Ca 2+ handling and regulation. The epithelial Ca 2+ channel ECaC1 (or
TRPV5) is the entry channel involved in active Ca 2+ transport. Ca 2+ entry is followed by
cytosolic diffusion, facilitated by calbindin-D 28K and/or calbindin-D 9k, and active extrusion
across the basolateral membrane by the Na+/Ca 2+-exchanger (NCX1) and plasma …