[HTML][HTML] Molecular features underlying the sequential phosphorylation of HS1 protein and its association with c-Fgr protein-tyrosine kinase
AM Brunati, A Donella-Deana, P James… - Journal of Biological …, 1999 - ASBMB
The hematopoietic lineage cell-specific protein HS1 was shown to undergo a process of
sequential phosphorylation bothin vitro and in vivo, which is synergistically mediated by Syk
and Src family protein-tyrosine kinases and essential for B cell antigen receptor-mediated
apoptosis. We have now identified tyrosine 222 as the HS1 residue phosphorylated by the
Src family protein kinases c-Fgr and Lyn, and we show that a truncated form of HS1 (HS1–
208-401) lacking the N-terminal putative DNA binding region and the C-terminal Src …
sequential phosphorylation bothin vitro and in vivo, which is synergistically mediated by Syk
and Src family protein-tyrosine kinases and essential for B cell antigen receptor-mediated
apoptosis. We have now identified tyrosine 222 as the HS1 residue phosphorylated by the
Src family protein kinases c-Fgr and Lyn, and we show that a truncated form of HS1 (HS1–
208-401) lacking the N-terminal putative DNA binding region and the C-terminal Src …