[HTML][HTML] Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4
Heparan sulfate-regulated transmembrane tyrosine kinase receptor FGFR4 is the major
FGFR isotype in mature hepatocytes. Fibroblast growth factor has been implicated in the
definition of liver from foregut endoderm where FGFR4 is expressed and stimulation of
hepatocyte DNA synthesis in vitro. Here we show that livers of mice lacking FGFR4 exhibited
normal morphology and regenerated normally in response to partial hepatectomy. However,
the FGFR4 (−/−) mice exhibited depleted gallbladders, an elevated bile acid pool and …
FGFR isotype in mature hepatocytes. Fibroblast growth factor has been implicated in the
definition of liver from foregut endoderm where FGFR4 is expressed and stimulation of
hepatocyte DNA synthesis in vitro. Here we show that livers of mice lacking FGFR4 exhibited
normal morphology and regenerated normally in response to partial hepatectomy. However,
the FGFR4 (−/−) mice exhibited depleted gallbladders, an elevated bile acid pool and …