Pathogenesis of bacterial meningitis

SL Leib, MG Täuber - Infectious disease clinics of North America, 1999 - Elsevier
Bacterial meningitis is the most common serious infection of the central nervous system.
Infection of the subarachnoid space leads to cerebrospinal fluid (CSF) inflammation,
meningeal irritation, and the clinical triad of headache, fever, and meningismus.
Approximately 10,000 cases of bacterial meningitis occur each year in the United States,
whereas other parts of the world have substantially higher incidences. 72 Even when treated
with highly effective antibiotics, the disease is fatal in 5% to 40% of the patients and causes …