Complement in allergy and asthma
NP Gerard, C Gerard - Current opinion in immunology, 2002 - Elsevier
NP Gerard, C Gerard
Current opinion in immunology, 2002•ElsevierThe complement system is a vital link between innate and adaptive immunity. Recently,
several investigators have implicated the complement anaphylatoxins C3a and C5a as
potential effectors in Type 1 hypersensitivity reactions, including urticaria, rhinitis and
asthma. Thus, complement activation may synergize with classical IgE mediated responses,
and inhibition of complement may prove therapeutic.
several investigators have implicated the complement anaphylatoxins C3a and C5a as
potential effectors in Type 1 hypersensitivity reactions, including urticaria, rhinitis and
asthma. Thus, complement activation may synergize with classical IgE mediated responses,
and inhibition of complement may prove therapeutic.
The complement system is a vital link between innate and adaptive immunity. Recently, several investigators have implicated the complement anaphylatoxins C3a and C5a as potential effectors in Type 1 hypersensitivity reactions, including urticaria, rhinitis and asthma. Thus, complement activation may synergize with classical IgE mediated responses, and inhibition of complement may prove therapeutic.
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