[HTML][HTML] Disruption of the endothelial cell protein C receptor gene in mice causes placental thrombosis and early embryonic lethality
JM Gu, JTB Crawley, G Ferrell, F Zhang, W Li… - Journal of Biological …, 2002 - ASBMB
The endothelial cell protein C receptor (EPCR) is a type 1 transmembrane protein found
primarily on endothelium that binds both protein C and activated protein C with similar
affinity. EPCR augments the activation of protein C by the thrombin-thrombomodulin
complex. To determine the physiological importance of EPCR, we generated EPCR-
deficient mice by homologous targeting in embryonic stem cells. Genotyping of progeny
obtained from EPCR+/− interbreeding indicated that EPCR−/− embryos died on or before …
primarily on endothelium that binds both protein C and activated protein C with similar
affinity. EPCR augments the activation of protein C by the thrombin-thrombomodulin
complex. To determine the physiological importance of EPCR, we generated EPCR-
deficient mice by homologous targeting in embryonic stem cells. Genotyping of progeny
obtained from EPCR+/− interbreeding indicated that EPCR−/− embryos died on or before …