[HTML][HTML] Specificity of coagulation factor signaling
W Ruf, A Dorfleutner, M Riewald - Journal of Thrombosis and Haemostasis, 2003 - Elsevier
Coagulation serine proteases signal through protease-activated receptors (PARs). Thrombin-
dependent PAR signaling on platelets is essential for the hemostatic response and vascular
thrombosis, but regulation of inflammation by PAR signaling is now recognized as an
important aspect of the pro-and anti-coagulant pathways. In tissue factor (TF)-dependent
initiation of coagulation, factor (F) Xa is the PAR-1 or PAR-2-activating protease when
associated with the transient TF–FVIIa–FXa complex. In the anticoagulant protein C (PC) …
dependent PAR signaling on platelets is essential for the hemostatic response and vascular
thrombosis, but regulation of inflammation by PAR signaling is now recognized as an
important aspect of the pro-and anti-coagulant pathways. In tissue factor (TF)-dependent
initiation of coagulation, factor (F) Xa is the PAR-1 or PAR-2-activating protease when
associated with the transient TF–FVIIa–FXa complex. In the anticoagulant protein C (PC) …