Molecular insights into mechanisms of iron transport
NC Andrews, MD Fleming, JE Levy - Current opinion in …, 1999 - journals.lww.com
NC Andrews, MD Fleming, JE Levy
Current opinion in hematology, 1999•journals.lww.comThe past 3 years have witnessed extraordinary progress in our understanding of mammalian
iron transport and homeostasis. The first transmembrane iron transporter has been found.
Mutations in this protein, in two animal models with iron-transport defects, have helped to
define the roles of this protein in vivo. The gene defective in patients with hereditary
hemochromatosis has been identified, and much has been learned about the structure and
function of its gene product. Finally, our ability to make a molecular diagnosis of hereditary …
iron transport and homeostasis. The first transmembrane iron transporter has been found.
Mutations in this protein, in two animal models with iron-transport defects, have helped to
define the roles of this protein in vivo. The gene defective in patients with hereditary
hemochromatosis has been identified, and much has been learned about the structure and
function of its gene product. Finally, our ability to make a molecular diagnosis of hereditary …
Abstract
The past 3 years have witnessed extraordinary progress in our understanding of mammalian iron transport and homeostasis. The first transmembrane iron transporter has been found. Mutations in this protein, in two animal models with iron-transport defects, have helped to define the roles of this protein in vivo. The gene defective in patients with hereditary hemochromatosis has been identified, and much has been learned about the structure and function of its gene product. Finally, our ability to make a molecular diagnosis of hereditary hemochromatosis has called attention to new iron-loading disorders, including African iron overload and juvenile hemochromatosis.
Lippincott Williams & Wilkins