[HTML][HTML] SPARC regulates the expression of collagen type I and transforming growth factor-β1 in mesangial cells

A Francki, AD Bradshaw, JA Bassuk, CC Howe… - Journal of Biological …, 1999 - ASBMB
The matricellular protein SPARC is expressed at high levels in cells that participate in tissue
remodeling and is thought to regulate mesangial cell proliferation and extracellular matrix
production in the kidney glomerulus in a rat model of glomerulonephritis (Pichler, RH,
Bassuk, JA, Hugo, C., Reed, MJ, Eng, E., Gordon, KL, Pippin, J., Alpers, CE, Couser, WG,
Sage, EH, and Johnson, RJ (1997) Am. J. Pathol. 148, 1153–1167). A potential mechanism
by which SPARC controls both cell cycle and matrix production has been attributed to its …