[HTML][HTML] SPARC (BM-40, osteonectin) inhibits the mitogenic effect of vascular endothelial growth factor on microvascular endothelial cells
C Kupprion, K Motamed, EH Sage - Journal of Biological Chemistry, 1998 - ASBMB
SPARC (secreted protein, acidic and rich in cysteine) is a matricellular protein that
modulates cell adhesion and proliferation and is thought to function in tissue remodeling
and angiogenesis. In this study, we demonstrate that SPARC inhibits DNA synthesis by>
90% in human microvascular endothelial cells (HMEC) stimulated by the endothelial cell
mitogen vascular endothelial growth factor (VEGF). Peptides derived from SPARC domain
IV, which contains a disulfide-bonded EF-hand sequence and binds to endothelial cells …
modulates cell adhesion and proliferation and is thought to function in tissue remodeling
and angiogenesis. In this study, we demonstrate that SPARC inhibits DNA synthesis by>
90% in human microvascular endothelial cells (HMEC) stimulated by the endothelial cell
mitogen vascular endothelial growth factor (VEGF). Peptides derived from SPARC domain
IV, which contains a disulfide-bonded EF-hand sequence and binds to endothelial cells …