Metabolic and genetic influence on glucose metabolism in type 2 diabetic subjects—experiences from relatives and twin studies
H Beck-Nielsen, A Vaag, P Poulsen… - Best Practice & Research …, 2003 - Elsevier
Based on our investigations in first-degree relatives, in twins in general, and in monozygotic
twins discordant for type 2 diabetes, we have studied the inheritance of glucose intolerance,
insulin resistance and insulin secretion in order to evaluate the role of genes versus
environment in the development of type 2 diabetes. Insulin resistance in type 2 diabetes is
mainly linked to glucose disposal in skeletal muscle, ie reduced glycogen synthesis. In order
to investigate the genetic component responsible for the reduced glycogen synthase activity …
twins discordant for type 2 diabetes, we have studied the inheritance of glucose intolerance,
insulin resistance and insulin secretion in order to evaluate the role of genes versus
environment in the development of type 2 diabetes. Insulin resistance in type 2 diabetes is
mainly linked to glucose disposal in skeletal muscle, ie reduced glycogen synthesis. In order
to investigate the genetic component responsible for the reduced glycogen synthase activity …