[HTML][HTML] Linkage disequilibrium maps and association mapping

NE Morton - The Journal of clinical investigation, 2005 - Am Soc Clin Investig
NE Morton
The Journal of clinical investigation, 2005Am Soc Clin Investig
The causal chain between a gene and its effect on disease susceptibility cannot be
understood until the effect has been localized in the DNA sequence. Recently,
polymorphisms incorporated in the HapMap Project have made linkage disequilibrium (LD)
the most powerful tool for localization. The genetics of LD, the maps and databases that it
provides, and their use for association mapping, as well as alternative methods for gene
localization, are briefly described.
The causal chain between a gene and its effect on disease susceptibility cannot be understood until the effect has been localized in the DNA sequence. Recently, polymorphisms incorporated in the HapMap Project have made linkage disequilibrium (LD) the most powerful tool for localization. The genetics of LD, the maps and databases that it provides, and their use for association mapping, as well as alternative methods for gene localization, are briefly described.
The Journal of Clinical Investigation