[HTML][HTML] Distinct domains of myocyte enhancer binding factor-2A determining nuclear localization and cell type-specific transcriptional activity
YT Yu - Journal of Biological Chemistry, 1996 - ASBMB
The myocyte enhancer binding factor 2 (MEF2) family of transcription factors plays an
important role in the regulation of gene expression in multiple muscle cell types. Four mef2
genes (A, B, C, and D) have been identified in vertebrates. They share the conserved N-
terminal MCM1-agamous-deficiens-serum response factor and MEF2 domains that
determine DNA binding and dimerization functions. In this study, we have identified human
MEF2A domains that control its nuclear localization and transcriptional activation function …
important role in the regulation of gene expression in multiple muscle cell types. Four mef2
genes (A, B, C, and D) have been identified in vertebrates. They share the conserved N-
terminal MCM1-agamous-deficiens-serum response factor and MEF2 domains that
determine DNA binding and dimerization functions. In this study, we have identified human
MEF2A domains that control its nuclear localization and transcriptional activation function …