[HTML][HTML] Functional organization of MIR2, a novel viral regulator of selective endocytosis
DJ Sanchez, L Coscoy, D Ganem - Journal of Biological Chemistry, 2002 - ASBMB
Kaposi's sarcoma-associated herpesvirus encodes two related proteins, MIR1 and MIR2,
that lead to reduction of the cell surface levels of major histocompatibility complex class I
and other polypeptides involved in immune recognition. MIR1 and MIR2 do not affect the
assembly or transport of their target proteins through the secretory pathway; rather, they act
to enhance the selective endocytosis of target chains from the cell surface. Sequence
inspection reveals that the modulator of immune recognition (MIR) proteins contain an NH 2 …
that lead to reduction of the cell surface levels of major histocompatibility complex class I
and other polypeptides involved in immune recognition. MIR1 and MIR2 do not affect the
assembly or transport of their target proteins through the secretory pathway; rather, they act
to enhance the selective endocytosis of target chains from the cell surface. Sequence
inspection reveals that the modulator of immune recognition (MIR) proteins contain an NH 2 …