Biopsy samples of liver were obtained from patients at operation for peptic ulcer, after they had received ordinary hospital diet with or without intravenous glucose or had been starved for 24 h with or without intravenous glucose. Liver glycogen, the only substance estimated which was significantly affected by the treatment, was low in the starved group, high after ordinary hospital diet plus glucose and intermediate and similar in the other two groups. There was a tendency to inverse variation of liver N, phospholipids and cholesterol with glycogen content, and a negative regression was found between glycogen and each of them, but no correlation with triglycerides. Amounts of N, phospholipids, cholesterol and triglycerides per unit deoxyribonucleic acid were not affected by variations in treatment.-E. Hobson.