[HTML][HTML] Determination of the tissue sites responsible for the catabolism of large high density lipoprotein in the African green monkey
KW Huggins, ER Burleson, JK Sawyer, K Kelly… - Journal of Lipid …, 2000 - ASBMB
In vivo multicompartmental modeling of the turnover of HDL subfractions has suggested that
HDL containing four molecules of apoA-I per particle and no other apolipoproteins (large
LpA-I) are terminal particles in plasma. We hypothesized that these terminal particles were
the end product of HDL metabolism and, as such, would be cleared preferentially by the
liver. Thus, the purpose of this study was to determine: 1) the tissue sites of catabolism of
large LpA-I in African green monkeys, and 2) whether saturated versus n–6 polyunsaturated …
HDL containing four molecules of apoA-I per particle and no other apolipoproteins (large
LpA-I) are terminal particles in plasma. We hypothesized that these terminal particles were
the end product of HDL metabolism and, as such, would be cleared preferentially by the
liver. Thus, the purpose of this study was to determine: 1) the tissue sites of catabolism of
large LpA-I in African green monkeys, and 2) whether saturated versus n–6 polyunsaturated …