[HTML][HTML] Mode of Action of Peroxisome Proliferators as Hypolipidemic Drugs.: SUPPRESSION OF APOLIPOPROTEIN C-III∗
R Hertz, J Bishara-Shieban, J Bar-Tana - Journal of Biological Chemistry, 1995 - ASBMB
The hypolipidemic effect exerted by β, β′-tetramethylhexadecanedioic acid (Medica 16) is
accounted for by enhanced catabolism of plasma triglyceride-rich lipoproteins due to a
decrease in plasma apolipoprotein C-III (Frenkel, B., Mayorek, N., Hertz, R., and Bar-Tana,
J.(1988) J. Biol. Chem. 263, 8491-8497; Frenkel, B., Bishara-Shieban, J., and Bar-Tana,
J.(1994) Biochem. J. 298, 409-414). Decrease in apolipoprotein C-III exerted by peroxisome
proliferators/hypolipidemic amphipathic carboxylates (eg Medica 16, fibrate drugs) is shown …
accounted for by enhanced catabolism of plasma triglyceride-rich lipoproteins due to a
decrease in plasma apolipoprotein C-III (Frenkel, B., Mayorek, N., Hertz, R., and Bar-Tana,
J.(1988) J. Biol. Chem. 263, 8491-8497; Frenkel, B., Bishara-Shieban, J., and Bar-Tana,
J.(1994) Biochem. J. 298, 409-414). Decrease in apolipoprotein C-III exerted by peroxisome
proliferators/hypolipidemic amphipathic carboxylates (eg Medica 16, fibrate drugs) is shown …