[HTML][HTML] Ameliorated hepatic insulin resistance is associated with normalization of microsomal triglyceride transfer protein expression and reduction in very low density …
A Carpentier, C Taghibiglou, N Leung, L Szeto… - Journal of Biological …, 2002 - ASBMB
To determine whether reduction of insulin resistance could ameliorate fructose-induced very
low density lipoprotein (VLDL) oversecretion and to explore the mechanism of this effect,
fructose-fed hamsters received placebo or rosiglitazone for 3 weeks. Rosiglitazone
treatment led to normalization of the blunted insulin-mediated suppression of the glucose
production rate and to a∼ 2-fold increase in whole body insulin-mediated glucose
disappearance rate (p< 0.001). Rosiglitazone ameliorated the defect in hepatocyte insulin …
low density lipoprotein (VLDL) oversecretion and to explore the mechanism of this effect,
fructose-fed hamsters received placebo or rosiglitazone for 3 weeks. Rosiglitazone
treatment led to normalization of the blunted insulin-mediated suppression of the glucose
production rate and to a∼ 2-fold increase in whole body insulin-mediated glucose
disappearance rate (p< 0.001). Rosiglitazone ameliorated the defect in hepatocyte insulin …