[HTML][HTML] Regulation of hepatic apolipoprotein B-lipoprotein assembly and secretion by the availability of fatty acids: I. Differential response to the delivery of fatty acids …
YL Zhang, A Hernandez-Ono, C Ko, K Yasunaga… - Journal of Biological …, 2004 - ASBMB
The in vivo effects of increased delivery of fatty acids (FA) to the liver are poorly defined.
Therefore, we compared the effects of infusing either 6 mm oleic acid (OA) bound to
albumin, 0.5-20% Intralipid, or saline for 3 or 6 h into male C57BL/6J mice. Infusions were
followed by studies of triglyceride (TG) and apoB secretion. Although plasma FA levels
increased similarly after either 20% Intralipid or 6 mm OA, TG secretion increased only after
infusion of 4-20% Intralipid; TG secretion was unchanged by 6 mm OA. By contrast, 6-h …
Therefore, we compared the effects of infusing either 6 mm oleic acid (OA) bound to
albumin, 0.5-20% Intralipid, or saline for 3 or 6 h into male C57BL/6J mice. Infusions were
followed by studies of triglyceride (TG) and apoB secretion. Although plasma FA levels
increased similarly after either 20% Intralipid or 6 mm OA, TG secretion increased only after
infusion of 4-20% Intralipid; TG secretion was unchanged by 6 mm OA. By contrast, 6-h …