[HTML][HTML] Three-fold effect of lovastatin treatment on low density lipoprotein metabolism in subjects with hyperlipidemia: increase in receptor activity, decrease in apoB …
L Berglund, JL Witztum, NF Galeano, AS Khouw… - Journal of lipid …, 1998 - ASBMB
To differentiate effects of lovastatin on low density lipoprotein (LDL) receptor activity from
effects on LDL metabolic properties, LDL apolipoprotein B (apoB) turnover was studied in
eight hyperlipidemic subjects during baseline and lovastatin treatment, in the latter case with
LDL tracers isolated during both baseline (C-LDL) and drug treatment (Rx-LDL) conditions.
Lovastatin (40 mg/day) significantly lowered total plasma and LDL cholesterol levels (27%
and 25%, respectively) as well as plasma triglyceride levels (30%). Using contemporaneous …
effects on LDL metabolic properties, LDL apolipoprotein B (apoB) turnover was studied in
eight hyperlipidemic subjects during baseline and lovastatin treatment, in the latter case with
LDL tracers isolated during both baseline (C-LDL) and drug treatment (Rx-LDL) conditions.
Lovastatin (40 mg/day) significantly lowered total plasma and LDL cholesterol levels (27%
and 25%, respectively) as well as plasma triglyceride levels (30%). Using contemporaneous …