Role of glucokinase and glucose-6-phosphatase in the acute and chronic regulation of hepatic glucose fluxes by insulin.
N Barzilai, L Rossetti - Journal of biological chemistry, 1993 - ASBMB
Increased hepatic glucose production (HGP) is the major cause of fasting hyperglycemia in
all forms of diabetes. Glucokinase (GK) and glucose-6-phosphatase (Glc-6-Pase) are the
proximal and the distal enzymatic steps, respectively, in the regulation of HGP. We
examined the impact of changes in GK and Glc-6-Pase activities on in vivo hepatic glucose
fluxes in diabetic (D) and control (C) rats. In particular, the acute regulation by insulin was
investigated using the euglycemic hyperinsulinemic clamp technique in conscious rats. In …
all forms of diabetes. Glucokinase (GK) and glucose-6-phosphatase (Glc-6-Pase) are the
proximal and the distal enzymatic steps, respectively, in the regulation of HGP. We
examined the impact of changes in GK and Glc-6-Pase activities on in vivo hepatic glucose
fluxes in diabetic (D) and control (C) rats. In particular, the acute regulation by insulin was
investigated using the euglycemic hyperinsulinemic clamp technique in conscious rats. In …