Glucokinase catalyzes a rate-limiting step in glucose metabolism in hepatocytes and
pancreatic β cells and is considered the" glucose sensor" for regulation of insulin secretion.
Patients with maturity-onset diabetes of the young (MODY) have heterozygous point
mutations in the glucokinase gene that result in reduced enzymatic activity and decreased
insulin secretion. However, it remains unclear whether abnormal liver glucose metabolism
contributes to the MODY disease. Here we show that disruption of the glucokinase gene …