Effects of SR141716A, a central cannabinoid receptor antagonist, on food-maintained responding

CS Freedland, JS Poston, LJ Porrino - Pharmacology Biochemistry and …, 2000 - Elsevier
Previous reports have indicated that administration of the central cannabinoid receptor
(CB1) antagonist SR141716A decreases intake of highly palatable food and drink.
Disruption of normal food intake has been reported only at high doses known to disrupt
spontaneous behaviors. The present study was designed to determine if rates of responding
for normal food were sensitive to the effects of cannabinoid receptor blockade. Adult, male
Sprague–Dawley rats were trained to lever press for normal food pellets under a fixed-ratio …