We describe a sporadic case of lethal prenatal onset infantile cortical hyperostosis (Caffey
disease), which resulted in early postnatal death at 30 weeks gestation. The mother
presented with antepartum haemorrhage and preterm labour. She was found to have
polyhydramnios. The infant showed extensive symmetrical diaphyseal subperiosteal cortical
thickening throughout the skeleton with short extremities. Hepatomegaly and lung
hypoplasia were present. Currently, in the absence of a specific marker, diagnostic …