[HTML][HTML] Characterization of the magnitude and kinetics of xanthine oxidase-catalyzed nitrite reduction: evaluation of its role in nitric oxide generation in anoxic tissues
H Li, A Samouilov, X Liu, JL Zweier - Journal of Biological Chemistry, 2001 - ASBMB
Xanthine oxidase (XO)-catalyzed nitrite reduction with nitric oxide (NO) production has been
reported to occur under anaerobic conditions, but questions remain regarding the
magnitude, kinetics, and biological importance of this process. To characterize this
mechanism and its quantitative importance in biological systems, electron paramagnetic
resonance spectroscopy, chemiluminescence NO analyzer, and NO electrode studies were
performed. The XO reducing substrates xanthine, NADH, and 2, 3-dihydroxybenz-aldehyde …
reported to occur under anaerobic conditions, but questions remain regarding the
magnitude, kinetics, and biological importance of this process. To characterize this
mechanism and its quantitative importance in biological systems, electron paramagnetic
resonance spectroscopy, chemiluminescence NO analyzer, and NO electrode studies were
performed. The XO reducing substrates xanthine, NADH, and 2, 3-dihydroxybenz-aldehyde …