[HTML][HTML] Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase
N Kuzkaya, N Weissmann, DG Harrison… - Journal of Biological …, 2003 - ASBMB
Tetrahydrobiopterin (BH 4) serves as a critical co-factor for the endothelial nitric-oxide
synthase (eNOS). A deficiency of BH 4 results in eNOS uncoupling, which is associated with
increased superoxide and decreased NO• production. BH 4 has been suggested to be a
target for oxidation by peroxynitrite (ONOO–), and ascorbate has been shown to preserve
BH 4 levels and enhance endothelial NO• production; however, the mechanisms underlying
these processes remain poorly defined. To gain further insight into these interactions, the …
synthase (eNOS). A deficiency of BH 4 results in eNOS uncoupling, which is associated with
increased superoxide and decreased NO• production. BH 4 has been suggested to be a
target for oxidation by peroxynitrite (ONOO–), and ascorbate has been shown to preserve
BH 4 levels and enhance endothelial NO• production; however, the mechanisms underlying
these processes remain poorly defined. To gain further insight into these interactions, the …