Despite expression of tumor-associated or tumor-specific antigens by most tumors, evasion
of protective T-cell immunity is the rule rather than the exception. Understanding whether
tumor immune escape primarily represents T-cell neglect, anergy/tolerance, or quantitative
limits of an existent immune response is central to developing new strategies to enhance
antitumor immunity. The authors studied the immune response to MB49, a tumor that
naturally expresses HY. Immune surveillance was effective following low-dose tumor …