Modulating angiogenesis: more vs less

B Sivakumar, LE Harry, EM Paleolog - Jama, 2004 - jamanetwork.com
The concept of manipulation of the vascular bed to either increase or decrease the number
of blood vessels has attracted considerable interest. This review focuses on angiogenesis
as a therapeutic target, particularly in the context of cancer and arthritis, as well as on
promoting angiogenesis in cardiovascular disease and the healing of bone fractures.
Although once touted almost as a panacea for treatment of tumors, as well as other diseases
associated with angiogenesis, such as diabetic retinopathy or rheumatoid arthritis, it is now …