[HTML][HTML] Increased levels of nuclear SREBP-1c associated with fatty livers in two mouse models of diabetes mellitus

I Shimomura, Y Bashmakov, JD Horton - Journal of Biological Chemistry, 1999 - ASBMB
Hepatic steatosis is common in non-insulin-dependent diabetes and can be associated with
fibrosis and cirrhosis in a subset of individuals. Increased rates of fatty acid synthesis have
been reported in livers from rodent models of diabetes and may contribute to the
development of steatosis. Sterol regulatory element-binding proteins (SREBPs) are a family
of regulated transcription factors that stimulate lipid synthesis in liver. In the current studies,
we measured the content of SREBPs in livers from two mouse models of diabetes, obese …