[HTML][HTML] Hepatocyte CYP2E1 overexpression and steatohepatitis lead to impaired hepatic insulin signaling
JM Schattenberg, Y Wang, R Singh, RM Rigoli… - Journal of Biological …, 2005 - ASBMB
Insulin resistance and increased cytochrome P450 2E1 (CYP2E1) expression are both
associated with and mechanistically implicated in the development of nonalcoholic fatty liver
disease. Although currently viewed as distinct factors, insulin resistance and CYP2E1
expression may be interrelated through the ability of CYP2E1-induced oxidant stress to
impair hepatic insulin signaling. To test this possibility, the effects of in vitro and in vivo
CYP2E1 overexpression on hepatocyte insulin signaling were examined. CYP2E1 …
associated with and mechanistically implicated in the development of nonalcoholic fatty liver
disease. Although currently viewed as distinct factors, insulin resistance and CYP2E1
expression may be interrelated through the ability of CYP2E1-induced oxidant stress to
impair hepatic insulin signaling. To test this possibility, the effects of in vitro and in vivo
CYP2E1 overexpression on hepatocyte insulin signaling were examined. CYP2E1 …