[HTML][HTML] Biochemistry and pharmacology of arachidonylethanolamide, a putative endogenous cannabinoid
CJ Hillard, WB Campbell - Journal of Lipid Research, 1997 - ASBMB
This review presents and explores the hypothesis that N-arachidonylethanolamine (AEA,
also called anandamide) is synthesized in the brain and functions as an endogenous ligand
of the cannabinoid receptor. Support for this hypothesis comes from in vitro experiments
demonstrating that AEA binds and activates signaling through the cannabinoid receptor. In
addition, in vivo AEA produces effects very similar to those of the classical agonists of the
cannabinoid receptor. Evidence for the cellular synthesis and release of AEA is not as clear …
also called anandamide) is synthesized in the brain and functions as an endogenous ligand
of the cannabinoid receptor. Support for this hypothesis comes from in vitro experiments
demonstrating that AEA binds and activates signaling through the cannabinoid receptor. In
addition, in vivo AEA produces effects very similar to those of the classical agonists of the
cannabinoid receptor. Evidence for the cellular synthesis and release of AEA is not as clear …