Alzheimer's disease and Down's syndrome: sharing of a unique cerebrovascular amyloid fibril protein
GG Glenner, CW Wong - Biochemical and biophysical research …, 1984 - Elsevier
GG Glenner, CW Wong
Biochemical and biophysical research communications, 1984•ElsevierThe cerebrovascular amyloid protein from a case of adult Down's syndrome was isolated
and purified. Amino acid sequence analysis showed it to be homologous to that of the β
protein of Alzheimer's disease. This is the first chemical evidence of a relationship between
Down's syndrome and Alzheimer's disease. It suggests that Down's syndrome may be a
predictable model for Alzheimer's disease. Assuming the β protein is a human gene product,
it also suggests that the genetic defect in Alzheimer's disease is localized on chromosome …
and purified. Amino acid sequence analysis showed it to be homologous to that of the β
protein of Alzheimer's disease. This is the first chemical evidence of a relationship between
Down's syndrome and Alzheimer's disease. It suggests that Down's syndrome may be a
predictable model for Alzheimer's disease. Assuming the β protein is a human gene product,
it also suggests that the genetic defect in Alzheimer's disease is localized on chromosome …
Abstract
The cerebrovascular amyloid protein from a case of adult Down's syndrome was isolated and purified. Amino acid sequence analysis showed it to be homologous to that of the β protein of Alzheimer's disease. This is the first chemical evidence of a relationship between Down's syndrome and Alzheimer's disease. It suggests that Down's syndrome may be a predictable model for Alzheimer's disease. Assuming the β protein is a human gene product, it also suggests that the genetic defect in Alzheimer's disease is localized on chromosome 21.
Elsevier