Isoform-specific binding of apolipoprotein E to beta-amyloid.
MJ LaDu, MT Falduto, AM Manelli, CA Reardon… - Journal of Biological …, 1994 - ASBMB
Apolipoprotein E (apoE), particularly the e4 allele, is genetically linked to the incidence of
Alzheimer's disease. ApoE is present in the extracellular senile plaques and intracellular
neurofibrillary tangles associated with Alzheimer's disease. In vitro, apoE has been shown to
bind beta-amyloid (A beta), an amyloidogenic proteolytic product of amyloid precursor
protein. To analyze the interaction of A beta and apoE, we used Western immunoblotting of
human A beta-(1-40)-peptide incubated with conditioned medium from HEK-293 cells …
Alzheimer's disease. ApoE is present in the extracellular senile plaques and intracellular
neurofibrillary tangles associated with Alzheimer's disease. In vitro, apoE has been shown to
bind beta-amyloid (A beta), an amyloidogenic proteolytic product of amyloid precursor
protein. To analyze the interaction of A beta and apoE, we used Western immunoblotting of
human A beta-(1-40)-peptide incubated with conditioned medium from HEK-293 cells …