[HTML][HTML] A molecular basis for insulin resistance: elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of …
K Paz, R Hemi, D LeRoith, A Karasik… - Journal of Biological …, 1997 - ASBMB
Tumor necrosis factor α (TNFα) or chronic hyperinsulinemia that induce insulin resistance
trigger increased Ser/Thr phosphorylation of the insulin receptor (IR) and of its major insulin
receptor substrates, IRS-1 and IRS-2. To unravel the molecular basis for this uncoupling in
insulin signaling, we undertook to study the interaction of Ser/Thr-phosphorylated IRS-1 and
IRS-2 with the insulin receptor. We could demonstrate that, similar to IRS-1, IRS-2 also
interacts with the juxtamembrane (JM) domain (amino acids 943–984) but not with the …
trigger increased Ser/Thr phosphorylation of the insulin receptor (IR) and of its major insulin
receptor substrates, IRS-1 and IRS-2. To unravel the molecular basis for this uncoupling in
insulin signaling, we undertook to study the interaction of Ser/Thr-phosphorylated IRS-1 and
IRS-2 with the insulin receptor. We could demonstrate that, similar to IRS-1, IRS-2 also
interacts with the juxtamembrane (JM) domain (amino acids 943–984) but not with the …