[HTML][HTML] Phosphorylation at the nuclear localization signal of Ca2+/calmodulin-dependent protein kinase II blocks its nuclear targeting
EK Heist, M Srinivasan, H Schulman - Journal of Biological Chemistry, 1998 - ASBMB
Translocation of protein kinases with broad substrate specificities between different
subcellular compartments by activation of signaling pathways is an established mechanism
to direct the activity of these enzymes toward particular substrates. Recently, we identified
two isoforms of Ca 2+/calmodulin-dependent protein kinase II (CaM kinase II), which are
targeted to the nucleus by an alternatively spliced nuclear localization signal (NLS). Here we
report that cotransfection with constitutively active mutants of CaM kinase I or CaM kinase IV …
subcellular compartments by activation of signaling pathways is an established mechanism
to direct the activity of these enzymes toward particular substrates. Recently, we identified
two isoforms of Ca 2+/calmodulin-dependent protein kinase II (CaM kinase II), which are
targeted to the nucleus by an alternatively spliced nuclear localization signal (NLS). Here we
report that cotransfection with constitutively active mutants of CaM kinase I or CaM kinase IV …