[HTML][HTML] Inhibitory cross-talk by cAMP kinase on the calmodulin-dependent protein kinase cascade
GA Wayman, H Tokumitsu, TR Soderling - Journal of Biological Chemistry, 1997 - ASBMB
The calmodulin-dependent kinase (CaM-K) cascade, a Ca 2+-triggered system involving
phosphorylation and activation of CaM-KI and CaM-KIV by CaM kinase kinase (CaM-KK),
regulates transcription through direct phosphorylation of transcription factors such as cAMP
response element-binding protein. We have shown previously that activated CaM-KIV can
activate the mitogen-activated protein kinases (Enslen, H., Tokumitsu, H., Stork, PJS, Davis,
RJ, and Soderling, TR (1996) Proc. Natl. Acad. Sci. USA 93, 10803–10808), and the present …
phosphorylation and activation of CaM-KI and CaM-KIV by CaM kinase kinase (CaM-KK),
regulates transcription through direct phosphorylation of transcription factors such as cAMP
response element-binding protein. We have shown previously that activated CaM-KIV can
activate the mitogen-activated protein kinases (Enslen, H., Tokumitsu, H., Stork, PJS, Davis,
RJ, and Soderling, TR (1996) Proc. Natl. Acad. Sci. USA 93, 10803–10808), and the present …