[HTML][HTML] Centromere protein b-null mice display decreasing reproductive performance through successive generations of breeding due to diminishing endometrial …
KJ Fowler, LH Wong, BK Griffiths, MC Sibson… - …, 2004 - rep.bioscientifica.com
KJ Fowler, LH Wong, BK Griffiths, MC Sibson, S Reed, KHA Choo
Reproduction, 2004•rep.bioscientifica.comCentromere protein B is a highly conserved constitutive protein found at centromeres. Gene
knockout studies in mice have unexpectedly identified Cenpb as a candidate gene involved
in uterine function. The present study further explores the role of Cenpb in mice by
intermating Cenpb-null mice over several generations. Breeding studies and analysis of
uterine tissue indicate that Cenpb-null mice lose reproductive fitness over a number of
generations due to a significant reduction in endometrial glands. These results suggest that …
knockout studies in mice have unexpectedly identified Cenpb as a candidate gene involved
in uterine function. The present study further explores the role of Cenpb in mice by
intermating Cenpb-null mice over several generations. Breeding studies and analysis of
uterine tissue indicate that Cenpb-null mice lose reproductive fitness over a number of
generations due to a significant reduction in endometrial glands. These results suggest that …
Centromere protein B is a highly conserved constitutive protein found at centromeres. Gene knockout studies in mice have unexpectedly identified Cenpb as a candidate gene involved in uterine function. The present study further explores the role of Cenpb in mice by intermating Cenpb -null mice over several generations. Breeding studies and analysis of uterine tissue indicate that Cenpb -null mice lose reproductive fitness over a number of generations due to a significant reduction in endometrial glands. These results suggest that Cenpb may play an important function in the short- and long-term maintenance of uterine integrity.
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