[HTML][HTML] Disruption of 12/15-lipoxygenase expression in peritoneal macrophages: enhanced utilization of the 5-lipoxygenase pathway and diminished oxidation of low …
Previously, we isolated the murine" leukocyte-type" 12-lipoxygenase (L-12LO) cDNA from
RNA of peritoneal-elicited cells that consisted predominantly of leukocytes (Chen, X.-S.,
Kurre, U., Jenkins, NA, Copeland, NG, and Funk, CD (1994) J. Biol. Chem. 269, 13979-
13987). By in situ hybridization we show that the L-12LO gene is expressed abundantly in a
subset of peritoneal macrophages but not in elicited leukocytes, alveolar macrophages, or
bone marrow-derived macrophages. L-12LO is highly related to human and rabbit 15 …
RNA of peritoneal-elicited cells that consisted predominantly of leukocytes (Chen, X.-S.,
Kurre, U., Jenkins, NA, Copeland, NG, and Funk, CD (1994) J. Biol. Chem. 269, 13979-
13987). By in situ hybridization we show that the L-12LO gene is expressed abundantly in a
subset of peritoneal macrophages but not in elicited leukocytes, alveolar macrophages, or
bone marrow-derived macrophages. L-12LO is highly related to human and rabbit 15 …