A small randomised trial of low-dose aspirin in women at high risk of pre-eclampsia

F Chiaffarino, F Parazzini, D Paladini, B Acaia… - European Journal of …, 2004 - Elsevier
Objective: To determine if aspirin (ASA) therapy reduces the incidence of pre-eclampsia in
women at high risk of this condition. Study design: Randomised clinical trial. We recruited
pregnant women with gestational age at randomisation< 14 weeks, who satisfied the
following criteria: chronic hypertension, history of severe pre-eclampsia or eclampsia or
intrauterine growth retardation (IUGR) or intrauterine foetal death. Nineteen women in the no-
treatment group and 16 in the ASA group were successfully followed up. Results: The mean …