[HTML][HTML] High density lipoprotein-induced endothelial nitric-oxide synthase activation is mediated by Akt and MAP kinases
C Mineo, IS Yuhanna, MJ Quon, PW Shaul - Journal of Biological Chemistry, 2003 - ASBMB
High density lipoprotein (HDL) activates endothelial nitric-oxide synthase (eNOS), leading to
increased production of the antiatherogenic molecule NO. A variety of stimuli regulate eNOS
activity through signaling pathways involving Akt kinase and/or mitogen-activated protein
(MAP) kinase. In the present study, we investigated the role of kinase cascades in HDL-
induced eNOS stimulation in cultured endothelial cells and COS M6 cells transfected with
eNOS and the HDL receptor, scavenger receptor BI. HDL (10–50 μg/ml, 20 min) caused …
increased production of the antiatherogenic molecule NO. A variety of stimuli regulate eNOS
activity through signaling pathways involving Akt kinase and/or mitogen-activated protein
(MAP) kinase. In the present study, we investigated the role of kinase cascades in HDL-
induced eNOS stimulation in cultured endothelial cells and COS M6 cells transfected with
eNOS and the HDL receptor, scavenger receptor BI. HDL (10–50 μg/ml, 20 min) caused …