[HTML][HTML] High density lipoprotein-induced signaling of the MAPK pathway involves scavenger receptor type BI-mediated activation of Ras
T Grewal, I de Diego, MF Kirchhoff, F Tebar… - Journal of Biological …, 2003 - ASBMB
High density lipoprotein (HDL) stimulates multiple signaling pathways. HDL-induced
activation of the mitogen-activated protein kinase (MAPK) pathway can be mediated by
protein kinase C (PKC) and/or pertussis toxin-sensitive G-proteins. Although HDL-induced
activation of MAPK involves Raf-1, Mek, and Erk1/2, the upstream contribution of p21 ras
(Ras) on the activation of Raf-1 and MAPK remains elusive. Here we examine the effect of
HDL on Ras activity and demonstrate that HDL induces PKC-independent activation of Ras …
activation of the mitogen-activated protein kinase (MAPK) pathway can be mediated by
protein kinase C (PKC) and/or pertussis toxin-sensitive G-proteins. Although HDL-induced
activation of MAPK involves Raf-1, Mek, and Erk1/2, the upstream contribution of p21 ras
(Ras) on the activation of Raf-1 and MAPK remains elusive. Here we examine the effect of
HDL on Ras activity and demonstrate that HDL induces PKC-independent activation of Ras …