[HTML][HTML] Reciprocal regulation of Neu tyrosine kinase activity and caveolin-1 protein expression in vitro and in vivo: implications for human breast cancer
Neu (c-erbB2) is a proto-oncogene product that encodes an epidermal growth factor-like
receptor tyrosine kinase. Amplification of wild-type c-Neuand mutational activation of Neu
(Neu T) have been implicated in oncogenic transformation of cultured fibroblasts and
mammary tumorigenesis in vivo. Here, we examine the relationship between Neu tyrosine
kinase activity and caveolin-1 protein expression in vitro and in vivo. Recent studies have
suggested that caveolins may function as negative regulators of signal transduction. Our …
receptor tyrosine kinase. Amplification of wild-type c-Neuand mutational activation of Neu
(Neu T) have been implicated in oncogenic transformation of cultured fibroblasts and
mammary tumorigenesis in vivo. Here, we examine the relationship between Neu tyrosine
kinase activity and caveolin-1 protein expression in vitro and in vivo. Recent studies have
suggested that caveolins may function as negative regulators of signal transduction. Our …