[HTML][HTML] The Designer cytokine hyper-interleukin-6 is a potent activator of STAT3-dependent gene transcription in vivoand in vitro
T Rakemann, M Niehof, S Kubicka, M Fischer… - Journal of Biological …, 1999 - ASBMB
Interleukin-6 (IL-6) triggers pivotal pathwaysin vivo. The designer protein hyper-IL-6 (H-IL-6)
fuses the soluble IL-6 receptor (sIL-6R) through an intermediate linker with IL-6. The
intracellular pathways that are triggered by H-IL-6 are not defined yet. Therefore, we studied
the molecular mechanisms leading to H-IL-6-dependent gene activation. H-IL-6 stimulates
haptoglobin mRNA expression in HepG2 cells, which is transcriptionally mediated as
assessed by run-off experiments. The increase in haptoglobin gene transcription correlates …
fuses the soluble IL-6 receptor (sIL-6R) through an intermediate linker with IL-6. The
intracellular pathways that are triggered by H-IL-6 are not defined yet. Therefore, we studied
the molecular mechanisms leading to H-IL-6-dependent gene activation. H-IL-6 stimulates
haptoglobin mRNA expression in HepG2 cells, which is transcriptionally mediated as
assessed by run-off experiments. The increase in haptoglobin gene transcription correlates …