Increased toxin-induced liver injury and fibrosis in interleukin-6-deficient mice
K Kovalovich, RA DeAngelis, W Li, EE Furth… - Hepatology, 2000 - journals.lww.com
Abstract Interleukin-6 null (IL-6−/−) mice have impaired liver regeneration and increased
liver necrosis following partial hepatectomy that is corrected with IL-6 treatment. Following
acute carbon tetrachloride (CCl 4) treatment, we found that IL-6−/− mice developed
increased hepatocellular injury and defective regeneration with significant blunting of signal
transducer-and-activator of transcription protein 3 (STAT3) and nuclear factor-κB (NF-κB)
activation and reduced hepatocyte DNA synthetic and mitotic responses. After CCl 4 …
liver necrosis following partial hepatectomy that is corrected with IL-6 treatment. Following
acute carbon tetrachloride (CCl 4) treatment, we found that IL-6−/− mice developed
increased hepatocellular injury and defective regeneration with significant blunting of signal
transducer-and-activator of transcription protein 3 (STAT3) and nuclear factor-κB (NF-κB)
activation and reduced hepatocyte DNA synthetic and mitotic responses. After CCl 4 …