The effect of circulating serum factors from patients with systemic lupus erythematosus on protein kinase A (PKA) activity and PKA-dependent protein phosphorylation …
GM Kammer, TM Haqqi, P Hasler… - Clinical immunology and …, 1993 - Elsevier
T lymphocytes from subjects with active systemic lupus erythematosus (SLE) exhibit reduced
cAMP-inducible, protein kinase A (PKA)-dependent phosphorylation of several intracellular
substrates compared with healthy and disease controls. To ascertain whether the persistent
T cell activation observed during active SLE can result in impaired PKA-dependent protein
phosphorylation, normal T cells were activated in vitro by monoclonal anti-CD3-ϵ antibody
and recombinant IL1-α (rIL1-α) for 24 hr. T cell activation, verified by IL2 mRNA, IL2 receptor …
cAMP-inducible, protein kinase A (PKA)-dependent phosphorylation of several intracellular
substrates compared with healthy and disease controls. To ascertain whether the persistent
T cell activation observed during active SLE can result in impaired PKA-dependent protein
phosphorylation, normal T cells were activated in vitro by monoclonal anti-CD3-ϵ antibody
and recombinant IL1-α (rIL1-α) for 24 hr. T cell activation, verified by IL2 mRNA, IL2 receptor …