The inherited basis of diabetes mellitus: implications for the genetic analysis of complex traits
JC Florez, J Hirschhorn… - Annual review of genomics …, 2003 - annualreviews.org
Annual review of genomics and human genetics, 2003•annualreviews.org
Diabetes encompasses a heterogeneous group of diseases, each with a substantial genetic
component. We review the division of diabetes into different subtypes based on clinical
phenotype, the fruitful pursuit of genes underlying monogenic forms of the disease, the
successes and drawbacks of whole-genome linkage scans in type 1 and type 2 diabetes,
and the recent identification of several diabetes genes by large association studies. We use
the lessons learned from this extensive body of evidence to illustrate general implications for …
component. We review the division of diabetes into different subtypes based on clinical
phenotype, the fruitful pursuit of genes underlying monogenic forms of the disease, the
successes and drawbacks of whole-genome linkage scans in type 1 and type 2 diabetes,
and the recent identification of several diabetes genes by large association studies. We use
the lessons learned from this extensive body of evidence to illustrate general implications for …
Diabetes encompasses a heterogeneous group of diseases, each with a substantial genetic component. We review the division of diabetes into different subtypes based on clinical phenotype, the fruitful pursuit of genes underlying monogenic forms of the disease, the successes and drawbacks of whole-genome linkage scans in type 1 and type 2 diabetes, and the recent identification of several diabetes genes by large association studies. We use the lessons learned from this extensive body of evidence to illustrate general implications for the genetic analysis of complex traits.
Annual Reviews