Parameters for reliable results in genetic association studies in common disease

I Dahlman, IA Eaves, R Kosoy, VA Morrison, J Heward… - Nature …, 2002 - nature.com
I Dahlman, IA Eaves, R Kosoy, VA Morrison, J Heward, SCL Gough, A Allahabadia…
Nature genetics, 2002nature.com
It is increasingly apparent that the identification of true genetic associations in common
multifactorial disease will require studies comprising thousands rather than the hundreds of
individuals employed to date. Using 2,873 families, we were unable to confirm a recently
published association of the interleukin 12B gene in 422 type I diabetic families. These
results emphasize the need for large datasets, small P values and independent replication if
results are to be reliable.
Abstract
It is increasingly apparent that the identification of true genetic associations in common multifactorial disease will require studies comprising thousands rather than the hundreds of individuals employed to date. Using 2,873 families, we were unable to confirm a recently published association of the interleukin 12B gene in 422 type I diabetic families. These results emphasize the need for large datasets, small P values and independent replication if results are to be reliable.
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