CD8-positive tumor-infiltrating lymphocytes influence the long-term survival of patients with mycosis fungoides
RT Hoppe, LJ Medeiros, RA Warnke… - Journal of the American …, 1995 - Elsevier
Background: Nonneoplastic mononuclear cells commonly infiltrate lesions of mycosis
fungoides. Objective: We sought to determine the immunophenotypic characteristics of these
cells and to determine whether the presence of CD8+ tumor-infiltrating lymphocytes has an
impact on prognosis. Methods: Skin biopsy specimens from 78 patients were stained with
immunopleroxidase techniques to determine their phenotypic characteristics. The proportion
of CD8+ tumor-infiltrating lymphocytes was quantified and compared with stage of disease …
fungoides. Objective: We sought to determine the immunophenotypic characteristics of these
cells and to determine whether the presence of CD8+ tumor-infiltrating lymphocytes has an
impact on prognosis. Methods: Skin biopsy specimens from 78 patients were stained with
immunopleroxidase techniques to determine their phenotypic characteristics. The proportion
of CD8+ tumor-infiltrating lymphocytes was quantified and compared with stage of disease …